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authorjwb <jwb@FreeBSD.org>2018-04-20 08:07:27 +0800
committerjwb <jwb@FreeBSD.org>2018-04-20 08:07:27 +0800
commitd000638d9a3c31cc4e8404152490d358f15854be (patch)
tree9dea7c85cd1f2fbded22dd7dacd50063db0c7b19 /biology
parent8adce11cc8888a56c211aafa07873e2b497da17b (diff)
downloadfreebsd-ports-gnome-d000638d9a3c31cc4e8404152490d358f15854be.tar.gz
freebsd-ports-gnome-d000638d9a3c31cc4e8404152490d358f15854be.tar.zst
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biology/freebayes: Bayesian haplotype-based polymorphism discovery and genotyping
Approved by: jrm (mentor) Differential Revision: https://reviews.freebsd.org/D15116
Diffstat (limited to 'biology')
-rw-r--r--biology/Makefile1
-rw-r--r--biology/freebayes/Makefile50
-rw-r--r--biology/freebayes/distinfo35
-rw-r--r--biology/freebayes/files/patch-Makefile20
-rw-r--r--biology/freebayes/files/patch-SeqLib_bwa_Makefile14
-rw-r--r--biology/freebayes/files/patch-SeqLib_bwa_bwt__lite.c10
-rw-r--r--biology/freebayes/files/patch-SeqLib_bwa_bwtgap.h10
-rw-r--r--biology/freebayes/files/patch-SeqLib_bwa_kthread.c10
-rw-r--r--biology/freebayes/files/patch-SeqLib_fermi-lite_Makefile12
-rw-r--r--biology/freebayes/files/patch-SeqLib_htslib_Makefile38
-rw-r--r--biology/freebayes/files/patch-src_LargeFileSupport.h11
-rw-r--r--biology/freebayes/files/patch-src_Makefile62
-rw-r--r--biology/freebayes/files/patch-vcflib_Makefile13
-rw-r--r--biology/freebayes/pkg-descr7
14 files changed, 293 insertions, 0 deletions
diff --git a/biology/Makefile b/biology/Makefile
index c4d3565e300f..5003301b151a 100644
--- a/biology/Makefile
+++ b/biology/Makefile
@@ -33,6 +33,7 @@
SUBDIR += fasttree
SUBDIR += fastx-toolkit
SUBDIR += fluctuate
+ SUBDIR += freebayes
SUBDIR += garlic
SUBDIR += gff2ps
SUBDIR += gmap
diff --git a/biology/freebayes/Makefile b/biology/freebayes/Makefile
new file mode 100644
index 000000000000..3d1fa422be62
--- /dev/null
+++ b/biology/freebayes/Makefile
@@ -0,0 +1,50 @@
+# $FreeBSD$
+
+PORTNAME= freebayes
+DISTVERSIONPREFIX= v
+DISTVERSION= 1.2.0
+CATEGORIES= biology
+
+MAINTAINER= jwb@FreeBSD.org
+COMMENT= Bayesian haplotype-based polymorphism discovery and genotyping
+
+LICENSE= MIT
+
+# Submodules use older versions than the ports, so we cannot safely unbundle
+# No shared libs are built by the submodules so there will be no conflicts
+USES= gmake tar:xz
+USE_GITHUB= yes
+GH_ACCOUNT= ekg
+GH_TUPLE= walaj:SeqLib:5941c68:SeqLib/SeqLib-temp \
+ jwalabroad:bwa:c02766e:bwa/SeqLib/bwa \
+ jwalabroad:fermi-lite:5bc90f8:fermi/SeqLib/fermi-lite \
+ samtools:htslib:49fdfbd:htslib/SeqLib/htslib \
+ ekg:bamtools:e77a43f:bamtools/bamtools \
+ ekg:intervaltree:dbb4c51:interval1/intervaltree \
+ vcflib:vcflib:5e3ce04:vcflib/vcflib-temp \
+ ekg:fastahack:c68cebb:fastahack/vcflib/fastahack \
+ ekg:filevercmp:1a9b779:filevercmp/vcflib/filevercmp \
+ ekg:fsom:a6ef318:fsom/vcflib/fsom \
+ google:googletest:d225acc:google/vcflib/googletest \
+ ekg:intervaltree:b704f19:interval2/vcflib/intervaltree \
+ ekg:multichoose:73d35da:multichoose/vcflib/multichoose \
+ ekg:smithwaterman:84c08d7:smithwaterman/vcflib/smithwaterman \
+ ekg:tabixpp:80012f8:tabixpp/vcflib/tabixpp \
+ samtools:htslib:0f298ce:hts2/vcflib/tabixpp/htslib
+
+# GCC disables sse2 by default on i386, but it's required for vcflib
+CXXFLAGS+= --std=c++11
+CFLAGS_i386= -msse2
+MAKE_JOBS_UNSAFE= yes
+PLIST_FILES= bin/bamleftalign bin/freebayes
+
+# GH_TUPLEs cannot seem to share a top-level subdirectory, so we work around
+# by dumping the parent in a temp directory and then moving the contents
+post-extract:
+ ${MV} -n ${WRKSRC}/SeqLib-temp/* ${WRKSRC}/SeqLib
+ ${MV} -n ${WRKSRC}/vcflib-temp/* ${WRKSRC}/vcflib
+
+do-install:
+ ${INSTALL_PROGRAM} ${WRKSRC}/bin/* ${STAGEDIR}${PREFIX}/bin
+
+.include <bsd.port.mk>
diff --git a/biology/freebayes/distinfo b/biology/freebayes/distinfo
new file mode 100644
index 000000000000..239c89905abb
--- /dev/null
+++ b/biology/freebayes/distinfo
@@ -0,0 +1,35 @@
+TIMESTAMP = 1523932688
+SHA256 (ekg-freebayes-v1.2.0_GH0.tar.gz) = a5626636112966cac87095365986722d1c871759f03c5a143646da65c416ba8a
+SIZE (ekg-freebayes-v1.2.0_GH0.tar.gz) = 2639725
+SHA256 (walaj-SeqLib-5941c68_GH0.tar.gz) = 0ac2b63f5fd7b1cec20a18ebb6799bf1f9b88d6c7cd95f7dd7410b1b82c8703f
+SIZE (walaj-SeqLib-5941c68_GH0.tar.gz) = 314968
+SHA256 (jwalabroad-bwa-c02766e_GH0.tar.gz) = cce547db0efef8572d63b47d2065f07e36f770fc8a6f15f5cd03d6fa9ab9b1f7
+SIZE (jwalabroad-bwa-c02766e_GH0.tar.gz) = 205546
+SHA256 (jwalabroad-fermi-lite-5bc90f8_GH0.tar.gz) = 2b3b9b637f48dc3239618efd6b55183eef6b6232013c217eb1c319f1dd3da224
+SIZE (jwalabroad-fermi-lite-5bc90f8_GH0.tar.gz) = 248454
+SHA256 (samtools-htslib-49fdfbd_GH0.tar.gz) = 0bc9c7d48e2a439badf5990113ae3e4de9acd05e4c090938236ee40588d115b9
+SIZE (samtools-htslib-49fdfbd_GH0.tar.gz) = 1145082
+SHA256 (ekg-bamtools-e77a43f_GH0.tar.gz) = d3a143636ccedcc54417a2d6d88dd726c7d2c046318620b88c7ba2fb30b01419
+SIZE (ekg-bamtools-e77a43f_GH0.tar.gz) = 540118
+SHA256 (ekg-intervaltree-dbb4c51_GH0.tar.gz) = 1f3ba92a83cb782cf22dfb383b8c93c11c1c88e0b2e5fa434e24668260ecd1f8
+SIZE (ekg-intervaltree-dbb4c51_GH0.tar.gz) = 3780
+SHA256 (vcflib-vcflib-5e3ce04_GH0.tar.gz) = d084c1df7bb0004df18e013da3cbf896b642d853c855aea58ae029abe1d2097a
+SIZE (vcflib-vcflib-5e3ce04_GH0.tar.gz) = 20119782
+SHA256 (ekg-fastahack-c68cebb_GH0.tar.gz) = c6f7186bbe733ff78c25b2afd7e7ba79daa3ecd14a5876ea0b033a43744c876d
+SIZE (ekg-fastahack-c68cebb_GH0.tar.gz) = 17312
+SHA256 (ekg-filevercmp-1a9b779_GH0.tar.gz) = 34c21d1b58295bca72b92c1cd832a4171b07ec97c19ffc0d4d8ec67e266c6070
+SIZE (ekg-filevercmp-1a9b779_GH0.tar.gz) = 3053
+SHA256 (ekg-fsom-a6ef318_GH0.tar.gz) = 68351c16d5c4b96142409e38c6828b6199eae44eaa7579bde165734d4832565b
+SIZE (ekg-fsom-a6ef318_GH0.tar.gz) = 9686
+SHA256 (google-googletest-d225acc_GH0.tar.gz) = 6880e0d51fa80a508ad5674ce483c1c468315faddac10d580b5505e8e7ef6bfa
+SIZE (google-googletest-d225acc_GH0.tar.gz) = 1279815
+SHA256 (ekg-intervaltree-b704f19_GH0.tar.gz) = 7e38b5f5873790afbcfdf6adbb621cdf4a1d9f22e28934a8edfe62cd65918f0d
+SIZE (ekg-intervaltree-b704f19_GH0.tar.gz) = 3768
+SHA256 (ekg-multichoose-73d35da_GH0.tar.gz) = af52475d7568863ad8173aebfb6b8b87690118bad8945876b629a2b3c05577cf
+SIZE (ekg-multichoose-73d35da_GH0.tar.gz) = 4697
+SHA256 (ekg-smithwaterman-84c08d7_GH0.tar.gz) = 299c9e28e50977642d1538f8940852976b6db3241619eb1f40b78484b1cde58e
+SIZE (ekg-smithwaterman-84c08d7_GH0.tar.gz) = 38382
+SHA256 (ekg-tabixpp-80012f8_GH0.tar.gz) = 6aecc865673776bec4e2ddb14e629a4798ad36bf8f7639968812a6262675fb3f
+SIZE (ekg-tabixpp-80012f8_GH0.tar.gz) = 3530
+SHA256 (samtools-htslib-0f298ce_GH0.tar.gz) = 829bb54383745fb923ed5d8dabbb6aa8b5d9501601c7a4163276d86aca1196ee
+SIZE (samtools-htslib-0f298ce_GH0.tar.gz) = 1065854
diff --git a/biology/freebayes/files/patch-Makefile b/biology/freebayes/files/patch-Makefile
new file mode 100644
index 000000000000..9c87b87ffbcb
--- /dev/null
+++ b/biology/freebayes/files/patch-Makefile
@@ -0,0 +1,20 @@
+--- Makefile.orig 2018-03-23 14:01:01 UTC
++++ Makefile
+@@ -5,7 +5,7 @@ wbamtools: vcflib/Makefile log
+ cd src && $(MAKE) -f Makefile.bamtools
+
+ log: src/version_git.h
+- wget -q http://hypervolu.me/freebayes/build/$(shell cat src/version_git.h | grep v | cut -f 3 -d\ | sed s/\"//g) &
++ # wget -q http://hypervolu.me/freebayes/build/$(shell cat src/version_git.h | grep v | cut -f 3 -d\ | sed s/\"//g) &
+
+ src/version_git.h:
+ cd src && $(MAKE) autoversion
+@@ -27,7 +27,7 @@ uninstall:
+ rm /usr/local/bin/freebayes /usr/local/bin/bamleftalign
+
+ test:
+- cd test && make test
++ cd test && ${MAKE} test
+
+ clean:
+ cd src && $(MAKE) clean
diff --git a/biology/freebayes/files/patch-SeqLib_bwa_Makefile b/biology/freebayes/files/patch-SeqLib_bwa_Makefile
new file mode 100644
index 000000000000..356ac3bd66ea
--- /dev/null
+++ b/biology/freebayes/files/patch-SeqLib_bwa_Makefile
@@ -0,0 +1,14 @@
+--- SeqLib/bwa/Makefile.orig 2018-03-23 18:47:04 UTC
++++ SeqLib/bwa/Makefile
+@@ -1,8 +1,8 @@
+-CC= gcc
++CC ?= gcc
+ #CC= clang --analyze
+-CFLAGS= -g -Wall -Wno-unused-function -O2
++CFLAGS ?= -g -Wall -Wno-unused-function -O2
+ WRAP_MALLOC=-DUSE_MALLOC_WRAPPERS
+-AR= ar
++AR ?= ar
+ DFLAGS= -DHAVE_PTHREAD $(WRAP_MALLOC)
+ ## moved is.o bwtiindex.o rope.o to LOBJS
+ LOBJS= utils.o kthread.o ksw.o bwt.o bntseq.o bwa.o bwamem.o bwamem_pair.o \
diff --git a/biology/freebayes/files/patch-SeqLib_bwa_bwt__lite.c b/biology/freebayes/files/patch-SeqLib_bwa_bwt__lite.c
new file mode 100644
index 000000000000..f664bd55c48a
--- /dev/null
+++ b/biology/freebayes/files/patch-SeqLib_bwa_bwt__lite.c
@@ -0,0 +1,10 @@
+--- SeqLib/bwa/bwt_lite.c.orig 2018-03-23 18:49:48 UTC
++++ SeqLib/bwa/bwt_lite.c
+@@ -1,6 +1,7 @@
+ #include <stdlib.h>
+ #include <string.h>
+ #include <stdio.h>
++#include <sys/types.h>
+ #include "bwt_lite.h"
+
+ #ifdef USE_MALLOC_WRAPPERS
diff --git a/biology/freebayes/files/patch-SeqLib_bwa_bwtgap.h b/biology/freebayes/files/patch-SeqLib_bwa_bwtgap.h
new file mode 100644
index 000000000000..4b2e4322b70a
--- /dev/null
+++ b/biology/freebayes/files/patch-SeqLib_bwa_bwtgap.h
@@ -0,0 +1,10 @@
+--- SeqLib/bwa/bwtgap.h.orig 2018-03-23 18:49:18 UTC
++++ SeqLib/bwa/bwtgap.h
+@@ -3,6 +3,7 @@
+
+ #include "bwt.h"
+ #include "bwtaln.h"
++#include <sys/types.h>
+
+ typedef struct { // recursion stack
+ u_int32_t info; // score<<21 | i
diff --git a/biology/freebayes/files/patch-SeqLib_bwa_kthread.c b/biology/freebayes/files/patch-SeqLib_bwa_kthread.c
new file mode 100644
index 000000000000..5193e4a2a2ab
--- /dev/null
+++ b/biology/freebayes/files/patch-SeqLib_bwa_kthread.c
@@ -0,0 +1,10 @@
+--- SeqLib/bwa/kthread.c.orig 2018-03-23 18:48:35 UTC
++++ SeqLib/bwa/kthread.c
+@@ -1,6 +1,7 @@
+ #include <pthread.h>
+ #include <stdlib.h>
+ #include <limits.h>
++#include <inttypes.h>
+
+ /************
+ * kt_for() *
diff --git a/biology/freebayes/files/patch-SeqLib_fermi-lite_Makefile b/biology/freebayes/files/patch-SeqLib_fermi-lite_Makefile
new file mode 100644
index 000000000000..ba795955ec76
--- /dev/null
+++ b/biology/freebayes/files/patch-SeqLib_fermi-lite_Makefile
@@ -0,0 +1,12 @@
+--- SeqLib/fermi-lite/Makefile.orig 2018-03-23 18:50:25 UTC
++++ SeqLib/fermi-lite/Makefile
+@@ -1,6 +1,6 @@
+-CC= gcc
+-CFLAGS= -g -Wall -O2 -Wno-unused-function #-fno-inline-functions -fno-inline-functions-called-once
+-CPPFLAGS=
++CC ?= gcc
++CFLAGS ?= -g -Wall -O2 -Wno-unused-function #-fno-inline-functions -fno-inline-functions-called-once
++CPPFLAGS ?=
+ INCLUDES=
+ OBJS= kthread.o misc.o \
+ bseq.o htab.o bfc.o \
diff --git a/biology/freebayes/files/patch-SeqLib_htslib_Makefile b/biology/freebayes/files/patch-SeqLib_htslib_Makefile
new file mode 100644
index 000000000000..e533e6ca5f45
--- /dev/null
+++ b/biology/freebayes/files/patch-SeqLib_htslib_Makefile
@@ -0,0 +1,38 @@
+--- SeqLib/htslib/Makefile.orig 2017-06-20 12:40:28 UTC
++++ SeqLib/htslib/Makefile
+@@ -22,20 +22,20 @@
+ # FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER
+ # DEALINGS IN THE SOFTWARE.
+
+-CC = gcc
+-AR = ar
+-RANLIB = ranlib
++CC ?= gcc
++AR ?= ar
++RANLIB ?= ranlib
+
+ # Default libraries to link if configure is not used
+ htslib_default_libs = -lz -lm -lbz2 -llzma
+
+-CPPFLAGS =
++CPPFLAGS ?=
+ # TODO: probably update cram code to make it compile cleanly with -Wc++-compat
+ # For testing strict C99 support add -std=c99 -D_XOPEN_SOURCE=600
+ #CFLAGS = -g -Wall -O2 -pedantic -std=c99 -D_XOPEN_SOURCE=600 -D__FUNCTION__=__func__
+-CFLAGS = -g -Wall -O2
++CFLAGS ?= -g -Wall -O2
+ EXTRA_CFLAGS_PIC = -fpic
+-LDFLAGS =
++LDFLAGS ?=
+ LIBS = $(htslib_default_libs)
+
+ prefix = /usr/local
+@@ -86,7 +86,7 @@ BUILT_THRASH_PROGRAMS = \
+ test/thrash_threads5 \
+ test/thrash_threads6
+
+-all: lib-static lib-shared $(BUILT_PROGRAMS) plugins $(BUILT_TEST_PROGRAMS)
++all: lib-static $(BUILT_PROGRAMS) plugins $(BUILT_TEST_PROGRAMS)
+
+ HTSPREFIX =
+ include htslib_vars.mk
diff --git a/biology/freebayes/files/patch-src_LargeFileSupport.h b/biology/freebayes/files/patch-src_LargeFileSupport.h
new file mode 100644
index 000000000000..60adfad0de8f
--- /dev/null
+++ b/biology/freebayes/files/patch-src_LargeFileSupport.h
@@ -0,0 +1,11 @@
+--- src/LargeFileSupport.h.orig 2018-03-23 21:15:04 UTC
++++ src/LargeFileSupport.h
+@@ -8,7 +8,7 @@ typedef __int64 off_type;
+ #define ftell64(a) ftell(a)
+ #define fseek64(a,b,c) fseek(a,b,c)
+ typedef __int64_t off_type;
+-#elif defined(__APPLE__)
++#elif defined(__APPLE__) || defined(__FreeBSD__)
+ #define ftell64(a) ftello(a)
+ #define fseek64(a,b,c) fseeko(a,b,c)
+ typedef off_t off_type;
diff --git a/biology/freebayes/files/patch-src_Makefile b/biology/freebayes/files/patch-src_Makefile
new file mode 100644
index 000000000000..cfe34b3b4ead
--- /dev/null
+++ b/biology/freebayes/files/patch-src_Makefile
@@ -0,0 +1,62 @@
+--- src/Makefile.orig 2018-03-23 14:01:01 UTC
++++ src/Makefile
+@@ -5,8 +5,9 @@
+ ################################################################################
+
+ # Compiler
+-CXX=g++ ${CXXFLAGS}
+-C=gcc
++CXX ?= g++
++# CXX += ${CXXFLAGS}
++CC ?= gcc
+
+ export CXXFLAGS
+ export C
+@@ -17,7 +18,7 @@ export LIBFLAGS
+
+ # Compiler flags
+
+-CFLAGS=-O3 -D_FILE_OFFSET_BITS=64 -g
++CFLAGS += -D_FILE_OFFSET_BITS=64
+ #CFLAGS=-O3 -static -D VERBOSE_DEBUG # enables verbose debugging via --debug2
+
+ SEQLIB_ROOT=../SeqLib
+@@ -25,7 +26,7 @@ VCFLIB_ROOT=../vcflib
+ TABIX_ROOT=$(VCFLIB_ROOT)/tabixpp
+ HTSLIB_ROOT=$(SEQLIB_ROOT)/htslib
+
+-LIBS = -lz -llzma -lbz2 -lm -lpthread
++LIBS = -lz -llzma -lbz2 -lm -lpthread -lexecinfo
+ INCLUDE = -I../src -I../ttmath -I$(VCFLIB_ROOT)/src/ -I$(VCFLIB_ROOT)/smithwaterman/ -I$(VCFLIB_ROOT)/multichoose/ -I$(VCFLIB_ROOT)/filevercmp/ -I$(VCFLIB_ROOT)/fastahack/ -I$(HTSLIB_ROOT) -I$(SEQLIB_ROOT)
+ #INCLUDE = -I../ttmath -I$(BAMTOOLS_ROOT)/src/ -I$(VCFLIB_ROOT)/src/ -I$(TABIX_ROOT)/ -I$(VCFLIB_ROOT)/smithwaterman/ -I$(VCFLIB_ROOT)/multichoose/ -I$(VCFLIB_ROOT)/filevercmp/ -I$(VCFLIB_ROOT)/fastahack/ -I$(HTSLIB_ROOT) -I$(SEQLIB_ROOT) -I$(SEQLIB_ROOT)/htslib
+
+@@ -46,10 +47,10 @@ gprof:
+ .PHONY: all static debug profiling gprof
+
+ $(HTSLIB_ROOT)/libhts.a:
+- cd $(HTSLIB_ROOT) && make
++ cd $(HTSLIB_ROOT) && ${MAKE}
+
+ $(SEQLIB_ROOT)/src/libseqlib.a:
+- cd $(SEQLIB_ROOT) && ./configure && make
++ cd $(SEQLIB_ROOT) && ./configure && ${MAKE}
+
+ OBJECTS=BedReader.o \
+ CNV.o \
+@@ -122,7 +123,7 @@ freebayes.o: freebayes.cpp TryCatch.h $(
+ $(CXX) $(CXXFLAGS) $(INCLUDE) -c freebayes.cpp
+
+ fastlz.o: fastlz.c fastlz.h
+- $(C) $(CFLAGS) $(INCLUDE) -c fastlz.c
++ $(CC) $(CFLAGS) $(INCLUDE) -c fastlz.c
+
+ Parameters.o: Parameters.cpp Parameters.h Version.h
+ $(CXX) $(CXXFLAGS) $(INCLUDE) -c Parameters.cpp
+@@ -277,5 +278,5 @@ autoversion:
+
+ clean:
+ rm -rf *.o *.cgh *~ freebayes alleles ../bin/freebayes ../bin/alleles ../vcflib/*.o ../vcflib/tabixpp/*.{o,a} tabix.hpp
+- if [ -d $(BAMTOOLS_ROOT)/build ]; then make -C $(BAMTOOLS_ROOT)/build clean; fi
+- make -C $(VCFLIB_ROOT)/smithwaterman clean
++ if [ -d $(BAMTOOLS_ROOT)/build ]; then ${MAKE} -C $(BAMTOOLS_ROOT)/build clean; fi
++ ${MAKE} -C $(VCFLIB_ROOT)/smithwaterman clean
diff --git a/biology/freebayes/files/patch-vcflib_Makefile b/biology/freebayes/files/patch-vcflib_Makefile
new file mode 100644
index 000000000000..c3df0fb79e6c
--- /dev/null
+++ b/biology/freebayes/files/patch-vcflib_Makefile
@@ -0,0 +1,13 @@
+--- vcflib/Makefile.orig 2018-03-23 18:36:07 UTC
++++ vcflib/Makefile
+@@ -136,8 +136,8 @@ all: $(OBJECTS) $(BINS)
+
+ GIT_VERSION := $(shell git describe --abbrev=4 --dirty --always)
+
+-CXX = g++
+-CXXFLAGS = -O3 -D_FILE_OFFSET_BITS=64 -std=c++0x
++CXX ?= g++
++CXXFLAGS += -D_FILE_OFFSET_BITS=64 -std=c++0x
+ #CXXFLAGS = -O2
+ #CXXFLAGS = -pedantic -Wall -Wshadow -Wpointer-arith -Wcast-qual
+
diff --git a/biology/freebayes/pkg-descr b/biology/freebayes/pkg-descr
new file mode 100644
index 000000000000..22f5fbd0373c
--- /dev/null
+++ b/biology/freebayes/pkg-descr
@@ -0,0 +1,7 @@
+FreeBayes is a Bayesian genetic variant detector designed to find small
+polymorphisms, specifically SNPs (single-nucleotide polymorphisms), indels
+(insertions and deletions), MNPs (multi-nucleotide polymorphisms), and complex
+events (composite insertion and substitution events) smaller than the length of
+a short-read sequencing alignment.
+
+WWW: https://github.com/ekg/freebayes