Pwytter is a multi-platform, standalone Twitter client written in Python
using Tkinter.  It currently features:

  - Switchable timelines: User (own tweets), Friends, Public, Replies,
    Direct messages, Composite
  - Clean and compact, themable user interface
  - Full Unicode support for all languages
  - Friends and Followers list display
  - Easy Replies and Direct Messages
  - In message URL detection
  - Image and request caching for fast UI response
  - Automatic and manual refresh
  - Pwytter update autodetection

WWW: http://www.pwytter.com/