Please read documentation on http://www.amavis.org/ before you start using it. To configure postfix, you have to do later: * add content_filter = vscan: to /usr/local/etc/postfix/main.cf * add vscan unix - n n - 10 pipe user=vscan argv=/usr/local/sbin/amavis ${sender} ${recipient} localhost:10025 inet n - n - - smtpd -o content_filter= to /etc/postfix/master.cf. Please read /usr/local/share/doc/amavis/README.postfix for further information